一、团队名称
中德生物医学中心
二、团队组成
负责人：胡康洪(博士、主任、二级教授)
成员：讲师（博士）1名、实验员1名（硕士）
三、团队介绍
本中心围绕影响人类健康和新发传染病病原的研究领域，在“病毒致病机理及抗病毒药物研发”及“干细胞介导的再生医学”等科学前沿致力于原始创新。主要研究内容为以乙型肝炎病毒（HBV）、致手足口病的肠道病毒71型（EV71）等高致病、高传染性病毒为研究对象，应用生物信息学方法、体外细胞培养系统、动物模型、人体组织四大系统，有机整合病毒学、医学、化学和药学等优势学术力量，阐明病毒感染复制机理，寻找具有新颖结构、优良抗病毒活性、新颖抗病毒机制的特异高效抗病毒药物，为病毒性疾病治疗奠定理论基础及开辟应用前景。另外，以独创的Hu3D®三维培养系统为平台，探索干细胞介导的肝肾组织再生、器官修复等再生医学前沿领域。
团队承担了国家“十一五”艾滋病和病毒性肝炎等重大传染病防治科技重大专项、国家“十二五”艾滋病和病毒性肝炎等重大传染病防治科技重大专项、国家自然科学基金面上项目、国家自然科学基金青年项目、湖北省自然科学基金重点项目、各类校企合作项目等，累计科研经费逾2000万元。
近五年发表SCI论文22篇，出版学术专著1本，获授权发明专利7项，培养博士研究生2名（与中科院合招）、硕士研究生11名，2018年和2019年分获中国人民解放军全军科技进步奖二等奖、中华预防医学会科技进步奖三等奖各1项。
四、科研成果
（1）代表性科研项目
1. 国家“十一五”艾滋病和病毒性肝炎等重大传染病防治科技重大专项，2008ZX10002-011，乙型病毒性肝炎病毒感染模型，2008.10-2010.12，结题，子课题主持。
2. 国家自然科学基金面上项目，3087013，SELEX 技术筛选抗 HBV 的诱饵分子， 2009.01-2011.12，结题，主持。
3. 国家“十二五”艾滋病和病毒性肝炎等重大传染病防治科技重大专项， 2012ZX10004508-008，HBV感染细胞和动物模型的建立和应用，2012.01-2015.12，结题，子课题主持。
4. 国家自然科学基金青年项目，31400153，PI3K/Akt信号通路在DHEA衍生物抗EV71中的作用研究，2015.01-2017.12，结题，主持。
5. 湖北省自然科学基金重点项目，2014CFA075，RNA诱饵分子抗HBV功效的体内研究，2015.01-2017.12，结题，主持。
6. 校企合作项目 “Hu3D®三维灌流式培养仪产业化”常州康珞生物科技公司委托 2018.01-2022.12，在研，主持
7. 校企合作项目 “新一代抗衰老干细胞抽提液”武汉润禾生物医药有限公司委托 2018.01-2020.12，在研，主持
（2）代表性成果获奖
1. 中国人民解放军全军科技进步奖二等奖 “乙型病毒性肝炎肝硬化的基础与临床研究” 2018年 （排名第二）
2. 中华预防医学会科学技术奖三等奖“乙型肝炎病毒细胞模型与乙型肝炎治疗新策略研究” 2019年（排名第二）
（3）代表性论文及专著
1. Yanhong Wei, Haijie Wang, Caili Xi, Ni Li, Dong Li, Chenguang Yao, Ge Sun, Hongmei Ge, Kanghong Hu*, Qian Zhang* 2020 “Antiviral effects of novel 2-benzoxyl-phenylpyridine derivatives” Molecules 25,1409; doi:10.3390/molecules25061490
2. 胡康洪参编 《中国学科发展战略 再生医学》科学出版社2020年ISBN 9787030434005
3. Xiaokang Hu, Huan Wang, Bo Huang, Ni Li, Kanghong Hu* et al. 2019 “A new scheme for rational design and synthesis of polyoxovanadate hybrids with high antitumor activities” Journal of Inorganic Biochemistry 193:130-132 doi: 10.1016/J.JINORGBIO.2019.01.013
4. Yao Chengguang#, Hu Kanghong# et al. 2019 “Transcriptomic analysis of cells in response to EV71 infection and 2Apro as a trigger for apoptosis via TXNIP gene” Genes & Genomics 41(3):343-357. doi: 10.1007/s13258-018-0760-7
5. Yao Chengguang, Xi Caili, Hu Kanghong, Gao Wa, Cai Xiaofeng, Qin Jinlan, Lv Shiyun, Du Canghao, Wei Yanhong* 2018 “Inhibition of enterovirus 71 replication and viral 3C protease by quercetin” Virology Journal 15(1):116. doi: 10.1186/s12985-018-1023-6.
6. Cheng M, Li N, Wang N, Hu K, Xiao Z*, Wu P*, Wei Y* 2018 “Synthesis, structure and antitumor studies of a novel decavanadate complex with a wavelike two-dimensional network” Polyhedron 155: 313-319. doi: 10.1016/J.POLY.2018.08.052
7. Ke S *, Li N, Ke T, Shi L, Zhang Z, Fang W, Zhang Y, Wang K, Zhou R, Wan Z, Yang Z, Zhang G, Wei Y* 2018 “Synthesis and evaluation of steroidal thiazoline conjugates as potential antiviral agents” Future Medicinal Chemistry 10 (22), 2589-2605. doi: 10.4155/fmc-2018-0075
8. Ji M, Hu K*. 2017 “Recent advances in the study of hepatitis B virus covalently closed circular DNA” Virologica Sinica 32(6):454-464 doi: 10.1007/S12250-017-4009-4
9. Ye Guoguo, Sun Ge, Cheng Zhikui, Zhang Lei, Hu Kanghong, Xia Xianmin*, Zhou Yin* 2017 “p55PIK regulates alpha-fetoprotein expression through the NF-kappa B signaling pathway” Life Sciences 191:104-110 doi: 10.1016/J.LFS.2017.09.043
10. Peng Ke, Honghao Sun, Mingxing Liu, Zhengding Su, Kanghong Hu et al. 2016 “Polymeric pH nanosensor with extended measurement range bearing octaarginine as cell penetrating peptide” IET Nanobiotechnology 10( 1): 8-12 doi: 10.1049/IET-NBT.2014.0070
11. Cheng Z, Zhi X, Sun G, Guo W, Zhao F, Hu K* 2016 “Sodium selenite suppresses hepatitis B virus transcription and replication in human hepatoma cell lines” Journal of Medical Virology 2016, 88(4): 653-663. doi: 10.1002/JMV.24366
12. Ye X, Zhou M, He Y, Wan Y, Bai W, Tao S, Ren Y, Zhang X, Xu J, Liu J, Zhang J*, Hu K*, Xie Y* 2016 Efficient Inhibition of Hepatitis B Virus Infection by a preS1-binding Peptide. Scientific Reports 6: 29391. doi: 10.1038/srep29391
13. Danzhen Pan , Yong Lin, Weimin Wu, Jingjiao Song, Ejuan Zhang, Chunchen Wu, Xinwen Chen, Kanghong Hu et al. 2015 “Persistence of the Recombinant Genomes of Woodchuck Hepatitis Virus in the Mouse Model” PloS One 10(5):e0125658 doi: 10.1371/JOURNAL.PONE.0125658
14. Cheng Z, Sun G, Guo W, Huang Y, Sun W, Zhao F, Hu K* 2015 “Inhibition of hepatitis B virus replication by quercetin in human hepatoma cell lines” Virologica Sinica 2015, 30(4): 261- 268. doi: 10.1007/S12250-015-3584-5
15. Zhou M, Huang Y, Cheng Z, Zhao F, Li J, Zhi X, Tian X, Sun W, Hu K* 2014 “Revival, characterization, and hepatitis B virus infection of cryopreserved human fetal hepatocytes” Journal of Virological Methods 2014, 207: 29-37. doi: 10.1016/J.JVIROMET.2014.06.015
16. Zhou M, Zhao F, Li J, Cheng Z, Tian X, Huang Y, Zhi X and Hu K* 2014 “Long-term maintenance of human fetal hepatocytes and prolonged susceptibility to HBV infection by co-culture with nonparenchymal cells” Journal of Virological Methods 195: 185-193. doi: 10.1016/J.JVIROMET.2013.10.010
17. Tian X, Zhao F, Sun W, Zhi X, Cheng Z, Zhou M, Hu K* 2014 “CRTC2 enhances HBV transcription and replication by inducing PGC1α expression” Virology Journal 11: 30. doi: 10.1186/1743-422X-11-30.
18. Tian X, Zhao F, Cheng Z, Zhou M, Zhi X, Li J, Hu K* 2013 “GCN5 acetyltransferase inhibits PGC1α-induced hepatitis B virus biosynthesis” Virologica Sinica 28(4):216-222. doi: 10.1007/S12250-013-3344-3
19. Chen P, Yun G, Na H, Wei F, Li J, Zhao F, Rayner S*, Hu K* 2013 “Computational evolutionary analysis of the overlapped surface (S) and polymerase (P) region in hepatitis B virus indicates the spacer domain in P is crucial for survival” PloS One 8(4): e60098. doi: 10.1371/JOURNAL.PONE.0060098
20. Feng H, Chen P, Zhao F, Nassal M*, Hu K* 2013 “Evidence for Multiple Distinct Interactions between Hepatitis B Virus P Protein and Its Cognate RNA Encapsidation Signal during Initiation of Reverse Transcription” Plos One, 2013, 8: e72798. doi: 10.1371/JOURNAL.PONE.0072798
21. Pan X, Li XJ, Liu XJ, Tian XH, Hu KH. et al. 2013 “Later Passage Neural Progenitor Cells from Neonatal Brain Are More Permissive for Human Cytomegalovirus Infection” Journal of Virology 87(20):10968-10979. doi: 10.1128/JVI.01120-13
22. Wang W, Peng H, Li J, Zhao X, Zhao F, Hu K* 2013 Controllable inhibition of hepatitis B virus replication by a DR1-targeting short hairpin RNA (shRNA) expressed from a DOX-inducible lentiviral vector. Virus Genes 2013, 46 (3): 393-403. doi: 10.1007/S11262-013-0886-2
23. Zhao Z, Hong W, Zeng Z, Wu Y, Hu K et al. 2012 “ucroporin-M1 inhibits hepatitis B virus replication by activating the MAPK pathawy and down-regulating HNF4α in vitro and in vivo” Journal of Biological Chemistry 287(36):30181-90. doi:10.1074/jbc.M112.370312
24. Feng H , Beck J, Nassal M and Hu K* 2011 “A SELEX-Screened aptamer of human hepatitis B virus RNA encapsidation signal suppresses viral replication” Plos One 6 (11): e27862. doi:10.1371/JOURNAL.PONE.0027862
25. Chen P , Rayner S*, and Hu K* 2011 “Advances of bioinformatics tools applied in virus epitopes prediction” Virologica Sinica 26(1):1-7 doi: 10.1007/s12250-011-3159-4
26. Hu K* 2010 “From Minu3D cultural system to aldosterone-induced tubulogenesis” Journal of Clinical Rehabilitative Tissue Engineering Research 14(2):365-369 doi:10.3969/j.issn.1673-8225.2010.02.041
27. Feng H and Hu K* 2009 “Structural Characteristics and Molecular Mechanism of Hepatitis B Virus Reverse Transcriptase” Virologica Sinica 24(6):509-517 doi: 10.1007/s12250-009-3076-6
28. Feng H and Hu K* 2008 “Aptamers against viral hepatitis from rational design to practical application” Virologica Sinica 23(5):315-320 doi:10.1007/s12250-008-2979-y
29. Minuth WW, Denk L, Hu K et al. 2007 “The tubulogenic effect of aldosterone is attributed to intact binding and intracellular response of the mineralocorticoid receptor” Central European Journal of Biology 2(3), 307-325 doi: 10.2478/S11535-007-0030-1
30. Minuth WW, Denk L and Hu K 2007 “The role of polyester interstitium and aldosterone during structural development of renal tubules in serum-free medium” Biomaterials 28(30), 4418-4428 doi: 10.1016/J.BIOMATERIALS.2007.06.031
31. Heber S, Denk L, Hu K 2007 “Modulating the development of renal tubules growing in serum-free culture medium at an artificial interstitium” Tissue Engineering 13(2), 281-292 doi:10.1089/TEN.2006.0199
32. Hu K et al. 2007 “Chemically defined medium determines the differential potency of renal stem cells” Biotechnology Journal 2(8), 992-995 doi:10.1002/BIOT.200700009
33. Hu K et al. 2005 “Characterization of the human zinc finger protein 267 promoter: essential role of nuclear factor Y” Biochimica Biophysica Acta 2005, 1729 (1): 14-23. doi:10.1016/J.BBAEXP.2005.03.001
34. Hu K et al. 2004 “SELEX-derived aptamers of the duck hepatitis B virus RNA encapsidation signal distinguish critical and non-critical residues for productive initiation of reverse transcription” Nucleic Acids Research 32(14): 4377-4389. doi: 10.1093/NAR/GKH772
35. Fels A, Hu K et al. 2001 “Transcription of potato spindle tuber viroid by RNA polymerase II starts predominatly at two specific sites” Nucleic Acids Research 29(22), 4589-4597 doi: 10.1093/NAR/29.22.4589
（4）代表性发明专利
1. 胡康洪、冯辉、周明；一种抗 HBV 诱饵适体及其筛选方法，2013-10-09，授权号ZL 201110410737.7
2. 胡康洪、王薇薇、彭洪泉； 利用慢病毒载体介导RNAi的方法 2013-11-27，授权号ZL201110110644.2
3. 胡康洪；一种三维灌流式细胞培养器，2014-07-23，授权号ZL201420033628.7
4. 胡康洪、周明、曹晓蓓；人原代肝细胞与肝非实质细胞共培养方法，2015-02-18，授权号ZL201310282851.5
5. 胡康洪、尧晨光、叶国国、朱祥、奚彩丽、成细瑶等；一种批量简易移液器枪头装盒装置，2017-10-03，授权号ZL201510596259.1
6. 胡康洪、黄亚运、程智逵、孙鸽、魏艳红； N-甲酰基-3,4-亚甲二氧基苄基-γ-丁内酯在制备抗乙型肝炎病毒药物中的应用，2018-11-23，授权号ZL201610407438.0
7. 魏艳红、李妮、胡康洪、吕诗韵、杜仓浩；氨基酸酯化合物在制备抗CVB3病毒药物中的应用, 2020-1-7, 授权号ZL201810751307.3.
8. 魏艳红、奚彩丽、张谦、李栋、胡康洪、尧晨光；二芳基甲酮化合物在制备抗肿瘤药物中的应用，2019-4-26, 授权号ZL 201611176431.9.
9. 魏艳红、奚彩丽、胡康洪、张谦、李栋、尧晨光; 芳香酯类化合物在制备抗肠道病毒71型药物中的应用, 2018-11-13, 授权号ZL 201611192748.1.
五、研究生毕业去向
1、博士研究生：与中科院联合培养的优秀毕业生进入省属三甲医院检验科工作或在985高校做博士后研究。
2、硕士研究生：
①攻读博士学位：推荐到某985高校免试攻读博士学位。
②企事业单位：推荐到中国生物医药集团等大型上市公司。
③报考公务员：考上政府部门公务员。
六、联系方式
联系人： 孙老师
电话：027-59750462
邮箱：hukh@hbut.edu.cn
